Cardioprotective effects of lidoflazine during 1-hour normothermic global ischemia.
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چکیده
منابع مشابه
Cardioprotective effects of lidoflazine during 1-hour normothermic global ischemia.
The cardioprotective effects of lidoflazine, a drug with calcium homeostatic properties, were investigated in dogs subjected to 1 hour of normothermic global ischemia, followed by reperfusion. None of the eight control dogs could be weaned from the extracorporeal bypass, confirming the severity of the ischemic model. All eight acutely pretreated dogs showed rapid recovery from the prolonged isc...
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It has been proposed that breakdown of the excitation-contraction coupling system plays a pivotal role in myocardial dysfunction during the course of acute ischemia. We tested this hypothesis by characterizing the function of the sarcoplasmic reticulum at pH 7.1 and 6.4 after 7.5, 15, and 30 minutes of canine normothermic global ischemia. At pH 7.1, whole heart homogenate sarcoplasmic reticulum...
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ژورنال
عنوان ژورنال: Circulation
سال: 1981
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.64.4.796